Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome

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Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome

Healthy pregnancy depends on proper placentation-including proliferation, differentiation, and invasion of trophoblast cells-which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia. Mechanisms regulating trophoblast invasion, however, are unknown. We report that reduction of Inverted formin 2 (INF2) alters intracellular trafficking and signifi...

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ژورنال

عنوان ژورنال: eLife

سال: 2018

ISSN: 2050-084X

DOI: 10.7554/elife.31150